Supplementary Figure S21 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

MAIN FINDING: The analysis identifies cell subtype-specific genetic control mechanisms in colorectal cancer.
KEY EVIDENCE: Relationships between eQTLs in single-cell versus bulk profiles are demonstrated in Supplementary Figure S21.
APPROACH: The study employs single-cell eQTL mapping to investigate genetic influences on cancer transformation.
SIGNIFICANCE: These insights may lead to targeted therapies for specific cell subtypes in colorectal cancer.

Supplementary figure illustrates eQTL relationships in single-cell and bulk profiles, highlighting genetic control in colorectal cancer progression.

Supplementary Figure 21 shows relationships between eQTLs identified in single-cell profiles and bulk profiles.

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Chen et al. (2025) studied this question.

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