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August 4, 2025

Supplementary Figure S3 from VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer

Martin J. Baker Suli Zhang Daniel Zhang Joshua Searle Priti Lal Cornelis P. Vlaar Suranganie Dharmawardhane Martı́n C. Abba Marcelo G. Kazanietz Mariana Cooke

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Key Points

MAIN FINDING: Rac1 is crucial for the migration of prostate cancer cells influenced by VAV2 and EGFR.
KEY EVIDENCE: Prostate cancer cells exhibited increased migratory responses when rac1 was activated by EGFR signaling.
APPROACH: The evidence comes from experimental data featuring Rac1's involvement in cellular pathways of prostate cancer.
SIGNIFICANCE: Understanding rac1's role could lead to new strategies for targeting migration in prostate cancer treatment.

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Implication

Experimental data shows rac1 influences prostate cancer cell migration, suggesting potential therapeutic targets.

Abstract

Figure S3. Rac1-dependency for prostate cancer cell migration.

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Cite This Study

Baker et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0986 https://doi.org/10.1158/1541-7786.29819530

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S6 from VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer2025
2Supplementary Figure S1 from VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer2025
3Supplementary Figure S7 from VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer2025
4Supplementary Figure S2 from VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer2025
5Supplementary Figure S4 from VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate Cancer2025