August 4, 2025

Figure 5 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles

Key Points

EV treatment with ovarian cancer EVs activates immune response pathways in secretory cells.
GO analysis indicates distinct signaling pathways upregulated by OVCAR3 EVs in ciliated cells.
Transcripts show significant changes in expression after one day of EV treatment in both cell types.
Understanding these pathways may improve therapeutic strategies for ovarian cancer management.

Abstract

EV treatment with ovarian cancer EVs induced immune responsive and chemokine signaling pathways. A and B, GO analysis showing pathways upregulated (B) and downregulated (C) by OVCAR3 EVs in secretory cells. C and D, GO analysis showing (C) biological pathways and (D) molecular functions upregulated in ciliated cells by OVCAR3 EVs. E and F, Heatmap showing transcripts upregulated and downregulated by OVCAR3 EVs in (E) secretory cells and (F) ciliated cells following 1 day of treatment.

Figure 5 from Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles

Key Points

Abstract

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