GO analysis reveals OVCAR3 EVs influence immune response and signaling pathways in ovarian cancer cells, suggesting new treatment avenues.
EV treatment with ovarian cancer EVs induced immune responsive and chemokine signaling pathways. A and B, GO analysis showing pathways upregulated (B) and downregulated (C) by OVCAR3 EVs in secretory cells. C and D, GO analysis showing (C) biological pathways and (D) molecular functions upregulated in ciliated cells by OVCAR3 EVs. E and F, Heatmap showing transcripts upregulated and downregulated by OVCAR3 EVs in (E) secretory cells and (F) ciliated cells following 1 day of treatment.
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Sipes et al. (2025) studied this question.
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