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August 4, 2025Open Access

Conduction pathway for potassium through the E. coli pump KdpFABC

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Authors

AHAdel HusseinXZXihui ZhangBPBjørn Panyella Pedersen

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Overview

Cryo-EM reveals K+ pathway in KdpFABC, highlighting its role in ion transport under osmotic stress.

Key Points

  • KdpFABC is an ATP-dependent pump that maintains potassium levels in bacteria under osmotic stress.
  • A 2.1 Å structure shows key features of the conduction pathway between KdpA and KdpB.
  • Membrane reconstitution and cryo-EM methods were used to image the KdpFABC pump under functional conditions.
  • The research underscores the partnership of the KdpFABC complex in sustaining bacterial survival by managing K+ gradients.

Cite This Study

Hussein et al. (2025) studied this question.

synapsesocial.com/papers/689a0f8de6551bb0af8d0cabhttps://doi.org/10.7554/elife.107397
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conduction pathway for potassium through the Escherichia coli pump KdpFABC2025
  2. 2On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC2025 · 1 citations
  3. 3BPS2026 – Lipids play a functional role in the potassium transport by KdpFABC2026
  4. 4Numerical model for electrogenic transport by the ATP-dependent potassium pump KdpFABC2024 · 11 citations
  5. 5KdpD is a tandem serine histidine kinase that controls K+ pump KdpFABC transcriptionally and post-translationally2024 · 14 citations