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November 13, 2025The Journal of General Physiology

On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC

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Authors

HMHridya Valia MadapallyAHAdel HusseinMEMartin Wazar Eriksen

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Overview

Molecular dynamics simulations showed potassium homeostasis in prokaryotes, highlighting the inter-subunit tunnel's role in K+ transport.

Key Points

  • K+ transport relies on a unique mechanism only allowing limited potassium movement, with water occupying the tunnel.
  • Key findings demonstrate a substantial barrier at the KdpA–KdpB interface that challenges existing models.
  • Analysis includes molecular dynamics simulations and biochemical assays to explore ion transport mechanisms.
  • These results suggest the need for further exploration of intermediate states for K+ translocation.

Cite This Study

Madapally et al. (2025) studied this question.

synapsesocial.com/papers/6941adef0f5af7fd17df5fechttps://doi.org/10.1085/jgp.202513794
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