Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 21, 2026Biophysical Journal

BPS2026 – Lipids play a functional role in the potassium transport by KdpFABC

View Full Paper
Ask AI
Bookmark
Share

Authors

AHAdel HusseinXZXihui ZhangDSDavid L. Stokes

Discussion

Loading...

Member takes

Overview

Cryo-EM reveals lipids' key impact on ATPase function and stability in KdpFABC, indicating their integral role.

Key Points

  • This research investigates the role of lipids in the potassium transport mechanism of KdpFABC.
  • Cryo-EM analysis of KdpFABC in lipid nanodiscs
  • Imaging under active turnover conditions
  • Structural comparison of reaction intermediates
  • Functional testing of mutations in subunit interfaces
  • Lipids are crucial for structure and function of the KdpFABC complex
  • Movement of lipids associates with transition states from E1∼P to E2-P
  • Bulky substitutions in residue mutations disrupt complex function and stability

Cite This Study

Hussein et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac295chttps://doi.org/10.1016/j.bpj.2025.11.2005
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conduction pathway for potassium through the E. coli pump KdpFABC2025 · 2 citations
  2. 2Conduction pathway for potassium through the Escherichia coli pump KdpFABC2025
  3. 3On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC2025 · 1 citations
  4. 4Numerical model for electrogenic transport by the ATP-dependent potassium pump KdpFABC2024 · 11 citations
  5. 5BPS2026 – Lipids influence the conformational dynamics of SthK2026