August 5, 2025

Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis

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High-mobility group box 1 demonstrated high diagnostic utility in acute exacerbations of idiopathic pulmonary fibrosis.
The study analyzed 779 HMGB1 readings from 269 patients, with a mean follow-up of 1.88 years.
Diagnostic performance showed area under the curve values greater than 0.75 for the methods used.
HMGB1 outperformed KL-6, suggesting its importance for earlier diagnosis and treatment of AE-IPF.

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Implication

Prospective cohort study shows high diagnostic accuracy of HMGB1 in identifying acute exacerbations, suggesting its potential use alongside KL-6 as biomarkers.

Cite This Study

Hamada et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d10b4 https://doi.org/10.21203/rs.3.rs-7162023/v1

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Implication

Prospective cohort study shows high diagnostic accuracy of HMGB1 in identifying acute exacerbations, suggesting its potential use alongside KL-6 as biomarkers.

Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis

Key Points

Discussion

Implication

Cite This Study

Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis

Key Points

Discussion

Implication

Cite This Study

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