What does this research mean for the field?

Serum HMGB1 is moderately associated with pulmonary hypertension in patients with acute exacerbations of COPD and, particularly when combined with endothelin-1 and PaCO2, provides utility for diagnostic and risk assessment in this acute setting. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the prognostic value of serum high-mobility group box 1 (HMGB1) in patients experiencing acute exacerbations of chronic obstructive pulmonary disease (AECOPD) complicated by pulmonary hypertension (PH), and to assess its correlation with inflammatory and vascular biomarkers.

August 23, 2026PulmonologyOpen Access

Utility of serum HMGB1 in chronic obstructive pulmonary disease with pulmonary hypertension: A single-centre analysis

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To evaluate the prognostic value of serum high-mobility group box 1 (HMGB1) in patients experiencing acute exacerbations of chronic obstructive pulmonary disease (AECOPD) complicated by pulmonary hypertension (PH), and to assess its correlation with inflammatory and vascular biomarkers.
Conducted a single-centre study analyzing 127 patients divided into an AECOPD-non-PH group (n = 71) and an AECOPD-PH group (n = 56).
Measured serum concentrations of HMGB1, IL-6, endothelin-1, TNF-α, and VEGF, assessing diagnostic performance via receiver operating characteristic (ROC) curves and multivariable logistic regression.
Serum HMGB1, endothelin-1, and PaCO2 were significantly higher in the AECOPD-PH cohort than in the non-PH cohort, with their combination yielding an area under the curve (AUC) of 0.751 for identifying PH.
HMGB1 levels correlated positively with IL-6 (ρ = 0.295, p = 0.001) and TNF-α (ρ = 0.302, p = 0.001), but negatively with VEGF (ρ = −0.232, p = 0.009).
An HMGB1 cutoff of ≥ 38.24 ng/mL predicted intermediate-to-high risk PH with 69.2% sensitivity, 64.7% specificity, and an AUC of 0.700.

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Implication

Observational study reveals elevated serum HMGB1 predicts pulmonary hypertension in acute COPD flare-ups, highlighting its potential utility for clinical risk stratification.

Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae407677a341144471c8 https://doi.org/10.1080/25310429.2026.2720837

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Implication

Observational study reveals elevated serum HMGB1 predicts pulmonary hypertension in acute COPD flare-ups, highlighting its potential utility for clinical risk stratification.

Utility of serum HMGB1 in chronic obstructive pulmonary disease with pulmonary hypertension: A single-centre analysis

Key Points

Discussion

Implication

Cite This Study

Utility of serum HMGB1 in chronic obstructive pulmonary disease with pulmonary hypertension: A single-centre analysis

Key Points

Discussion

Implication

Cite This Study

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