What question did this study set out to answer?

To evaluate the diagnostic utility of serial serum high-mobility group box 1 (HMGB1) measurements for identifying acute exacerbations in patients with idiopathic pulmonary fibrosis (AE-IPF).

November 5, 2025Scientific ReportsOpen Access

Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis

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To evaluate the diagnostic utility of serial serum high-mobility group box 1 (HMGB1) measurements for identifying acute exacerbations in patients with idiopathic pulmonary fibrosis (AE-IPF).
Conducted a prospective, multicenter, observational cohort study involving 269 Japanese patients with idiopathic pulmonary fibrosis (779 total HMGB1 measurements) followed for a mean of 1.88 years (505.6 person-years).
Evaluated diagnostic accuracy across four methods of serial HMGB1 tracking and compared results with serum KL-6 levels during stable disease and acute exacerbations.
Recorded 46 cases of acute exacerbations alongside corresponding serum HMGB1 measurements during follow-up.
Achieved high diagnostic accuracy across all four serial HMGB1 assessment methods, each showing an area under the curve (AUC) > 0.75.
Demonstrated significantly superior diagnostic performance for serum HMGB1 compared with serum KL-6 in identifying acute exacerbations.

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Implication

Prospective cohort study reveals high diagnostic accuracy of serum HMGB1 for acute exacerbations in idiopathic pulmonary fibrosis, suggesting utility for earlier clinical detection.

Cite This Study

Hamada et al. (2025) studied this question.

synapsesocial.com/papers/6aa0202a77cb84a8daef7aaf https://doi.org/10.1038/s41598-025-22422-3

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Implication

Prospective cohort study reveals high diagnostic accuracy of serum HMGB1 for acute exacerbations in idiopathic pulmonary fibrosis, suggesting utility for earlier clinical detection.

Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis

Key Points

Discussion

Implication

Cite This Study

Diagnostic utility of high-mobility group box 1 for acute exacerbations of idiopathic pulmonary fibrosis

Key Points

Discussion

Implication

Cite This Study

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