What does this research mean for the field?

Serum high mobility group box 1 (HMGB1) levels can accurately diagnose infections and predict the need for intensive care unit admission in patients with cirrhosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the efficacy of high mobility group box 1 (HMGB1) as a biomarker for diagnosing infections and predicting intensive care unit admission in patients with liver cirrhosis.

August 29, 2026Egyptian Liver JournalOpen Access

High mobility group box 1 as a potential diagnostic and prognostic biomarker in Egyptian cirrhotic patients with infection

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To evaluate the efficacy of high mobility group box 1 (HMGB1) as a biomarker for diagnosing infections and predicting intensive care unit admission in patients with liver cirrhosis.
Included 88 participants stratified into 34 cirrhotic patients with infection, 30 cirrhotic patients without infection, and 24 healthy controls.
Measured serum HMGB1 levels and analyzed their relationships with neutrophil counts, CRP levels, and liver severity metrics including Child–Pugh and MELD-Na scores.
HMGB1 levels correlated positively with neutrophil counts and CRP levels, but showed no significant association with MELD-Na or Child–Pugh scores.
A serum HMGB1 cut-off value of > 3.24 µg/L demonstrated 90.9% sensitivity and 95.65% specificity for distinguishing patients requiring intensive care unit admission from those managed in general wards.

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Implication

Comparative study reveals high mobility group box 1 predicts intensive care admission in cirrhotic patients with infections, suggesting strong diagnostic and prognostic utility.

Cite This Study

Kassem et al. (2026) studied this question.

synapsesocial.com/papers/6a92994d8e5d7d1fc0c1122a https://doi.org/10.1186/s43066-026-00543-2

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Implication

Comparative study reveals high mobility group box 1 predicts intensive care admission in cirrhotic patients with infections, suggesting strong diagnostic and prognostic utility.

High mobility group box 1 as a potential diagnostic and prognostic biomarker in Egyptian cirrhotic patients with infection

Key Points

Discussion

Implication

Cite This Study

High mobility group box 1 as a potential diagnostic and prognostic biomarker in Egyptian cirrhotic patients with infection

Key Points

Discussion

Implication

Cite This Study

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