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August 4, 2025

Supplementary Figure 9 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations

Yinghong Lu Lixia Xu Weikang Chen Weixin Liu Ying Zhang Qianying Zhou Na Wang Yongxin Zhang Haojie Bai Shu Xu Pingmei Huang Kaili Fu Wenxuan Xie Xin Liu Xueliang Wang Chi Chun Wong Ming Kuang Jun Yu

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Key Points

MAIN FINDING: Intrahepatic microbial heterogeneity significantly contributes to the growth of hepatocellular carcinoma (HCC).
KEY EVIDENCE: The presence of specific intrahepatic bacteria is associated with enhanced tumor metastasis.
APPROACH: The study analyzed genomic and transcriptomic alterations in multifocal cases of HCC to understand the microbial impact.
SIGNIFICANCE: These findings highlight the crucial role of microbial populations in cancer progression, suggesting new therapeutic targets.

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Implication

Research demonstrates microbial heterogeneity's influence on tumor growth in hepatocellular carcinoma, suggesting link with genomic alterations.

Abstract

Intrahepatic bacteria promote HCC tumor growth and metastasis

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Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d10e4 https://doi.org/10.1158/2159-8290.29819805

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 1 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025
2Supplementary Figure 3 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025
3Supplementary Figure 11 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025
4Supplementary Figure 10 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025
5Supplementary Figure 5 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025