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August 4, 2025

Supplementary Figure 11 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations

Yinghong Lu Lixia Xu Weikang Chen Weixin Liu Ying Zhang Qianying Zhou Na Wang Yongxin Zhang Haojie Bai Shu Xu Pingmei Huang Kaili Fu Wenxuan Xie Xin Liu Xueliang Wang Chi Chun Wong Ming Kuang Jun Yu

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Key Points

MAIN FINDING: Intrahepatic microbial heterogeneity is observed in multifocal hepatocellular carcinoma (HCC).
KEY EVIDENCE: Detailed single-cell atlases depict unique tumor-associated microbiota within local microniches.
APPROACH: The research utilizes high-dimensional analysis to study genomic and transcriptomic alterations in HCC.
SIGNIFICANCE: Understanding microbial roles in HCC could lead to novel diagnostic and therapeutic strategies.

Implication

Single-cell analysis reveals microbial heterogeneity in multifocal HCC, indicating links to genomic and transcriptomic changes.

Abstract

Single cell, high dimensional atlases of multifocal HCC and tumor associated microbiota in local microniches

Discussion

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Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d10e5 https://doi.org/10.1158/2159-8290.29819832

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 1 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025
2Supplementary Figure 3 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025
3Supplementary Figure 9 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025
4Supplementary Figure 10 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025
5Supplementary Figure 5 from Intrahepatic Microbial Heterogeneity in Multifocal Hepatocellular Carcinoma and Its Association with Host Genomic and Transcriptomic Alterations2025