This review discusses immunomodulation of macrophage phenotypes to prevent inflammatory diseases in Leishmania and Trypanosoma cruzi infections, suggesting novel therapeutic strategies.
Key Points
Main finding: Modulating macrophage phenotypes can prevent chronic infections caused by Leishmania and Trypanosoma cruzi.
Key evidence: Strategies include inducing M1 proinflammatory responses and inhibiting M2 pro-infection responses.
Approach: Experimental models tested pharmacological methods to influence macrophage activation during protozoan infections.
Significance: Understanding macrophage roles could lead to new treatments for inflammatory diseases linked to protozoan infections.