August 11, 2025Open Access

scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues

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Exploratory analysis elucidates dual TCR Treg characteristics in mouse lymphoid and non-lymphoid tissues, indicating potential functional diversity.

A high proportion of dual TCR Tregs was found in various mouse tissues, showing unique pairing patterns and gene usage.
Over 5,000 T cells were analyzed using scRNA+TCR-seq technology, focusing on their characteristics and mRNA expressions.
This study highlighted the diversity of dual TCR Treg cells, showing both homogeneity and variability compared to single TCR Tregs.
The findings suggest new avenues for investigating Treg cells' origins and roles in different tissue environments.

Xu et al. (2025) studied this question.

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Exploratory analysis elucidates dual TCR Treg characteristics in mouse lymphoid and non-lymphoid tissues, indicating potential functional diversity.