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September 19, 2025Open Access

scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues

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Authors

YXYuanyuan XuQPQi PengXLXiaoping Lu

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Overview

Utilizing scrna+tcr-seq reveals proportions and characteristics of dual tcr treg cells in lymphoid and non-lymphoid tissues, suggesting their unique function and diversity.

Key Points

  • A high proportion of dual TCR Treg cells were identified in mouse tissues, indicating their possible unique roles.
  • Analysis of over 5,000 T cells showed distinct TCR pairing patterns and mRNA expression profiles between dual and single TCR Tregs.
  • Comparative studies against shared databases provided insights on the tissue distribution and characteristics of dual TCR Tregs.
  • The research highlights the importance of dual TCR Treg cells, suggesting extensive implications for understanding T cell development and tolerance.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d46cd731b076d99fa69322https://doi.org/10.7554/elife.105504.3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues2025
  2. 2Dual T cell receptor expression provides intrinsic advantage for agonist selection of thymic FoxP3+ regulatory T cells (Tregs) in the neonatal thymus2026
  3. 3scRNA+ TCR-seq revealed dual TCR T cells antitumor response in the TME of NSCLC2024 · 4 citations
  4. 4Identification of unconventional Dual TCR clonotypes and their capacity to evade thymic selection 47072025
  5. 5DeRR: A Unique Detecting Method and the First Landscape for T Cells with Dual T Cell Receptors from Large-scale Single Cell Data2025 · 1 citations