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October 8, 2025Genomics Proteomics & BioinformaticsOpen Access

DeRR: A Unique Detecting Method and the First Landscape for T Cells with Dual T Cell Receptors from Large-scale Single Cell Data

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Authors

SCSi‐Yi ChenLMLingzi MaoXFXin Fu

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Overview

Computational pipeline identifies dual-tcr T cells in single-cell data, suggesting implications for immunology.

Key Points

  • DeRR reveals that about 17% of T cells carry dual TCR α-chains, highlighting the complexity of T cell populations.
  • Analysis of over 600,000 single T cells showed an elevated dual-TCR frequency in cancer compared to other conditions.
  • The unique detection method demonstrates greater cross-reactivity in dual-TCR T cells than in single-TCR counterparts.
  • Dynamic expression of TCRs within dual-TCR T cells suggests a need for further exploration of their functional roles.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1b46950a706b22b4e9bhttps://doi.org/10.1093/gpbjnl/qzaf090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues2025
  2. 2scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues2025
  3. 3Identification of unconventional Dual TCR clonotypes and their capacity to evade thymic selection 47072025
  4. 4scRNA+ TCR-seq revealed dual TCR T cells antitumor response in the TME of NSCLC2024 · 4 citations
  5. 5Abstract 3976: Single-cell TCRɑ/β and TCRγ/δ immune receptor profiling and immunophenotyping using a 96-well plate sorted-cell approach2024 · 1 citations