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November 1, 2025The Journal of ImmunologyOpen Access

Identification of unconventional Dual TCR clonotypes and their capacity to evade thymic selection 4707

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Authors

PDParker Dow

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Overview

Research shows dual TCR clonotypes evade thymic selection in T cells, suggesting implications for autoreactivity.

Key Points

  • This study aims to identify dual TCR clonotypes that evade thymic selection and examine their potential autoreactivity.
  • Utilized a dual TCRα transgenic reporter mouse model to isolate single and dual CD4+ and CD8+ T cells.
  • Developed a pipeline for identifying dual TCR-associated clonotypes from single-cell TCR sequences.
  • Conducted retrogenic cloning of dual TCRs into RAG deficient mice to assess thymic emigration.
  • Found that dual TCR cells with atypical TCRs are paired with conventional TCRs.
  • Identified that atypical dual TCR chains associate with known autoreactive TCRs.
  • Confirmed that dual TCR expression facilitates the thymic emergence of atypical receptors.

Cite This Study

Parker Dow (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc359828https://doi.org/10.1093/jimmun/vkaf283.2348
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dual T cell receptor expression provides intrinsic advantage for agonist selection of thymic FoxP3+ regulatory T cells (Tregs) in the neonatal thymus2026
  2. 2scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues2025
  3. 3scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues2025
  4. 4Proportion, Function, and Generation of Dual Receptor Lymphocytes2026 · 1 citations
  5. 5Capturing and tracking clonal T cell response to cancer neoantigens2026 · 1 citations