Crocin's Protective Effect Against a Valproate-Exposed Model of Autism Spectrum Disorder: A Histological and Oxido-Inflammatory Investigation

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Experimental analysis shows crocin mitigates inflammation and oxidative stress in rats with ASD, indicating potential therapeutic benefits.

Crocin significantly improved histological and inflammatory changes in rats exposed to valproate, suggesting its protective effects against autism spectrum disorder.
Following valproate exposure, elevated inflammatory markers were observed, while crocin treatment reduced these markers, restoring mitochondrial function.
The intervention used Wistar albino rats, with valproate administered to induce autism, followed by crocin treatment to examine neuroprotection.
These findings support further research into crocin as a potential treatment for autism spectrum disorder with anti-inflammatory properties.

Majhi et al. (2025) studied this question.

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Experimental analysis shows crocin mitigates inflammation and oxidative stress in rats with ASD, indicating potential therapeutic benefits.