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August 19, 2025Smart MoleculesOpen Access

A ratiometric fluorescent probe monitoring lipid peroxidation within lipid droplets in foam cells

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Authors

DLDingxuan LiCLCaiwei LuSSShulan Sun

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Overview

Novel fluorescent probe tracks lipid peroxidation in foam cells, indicating its role in atherosclerosis progression.

Key Points

  • Lipid peroxidation in foam cells correlates with lipid uptake, affecting atherosclerosis progression.
  • The Ld-LPO probe shows a fluorescence shift from 590 to 525 nm, enabling precise imaging of lipid droplets.
  • Analysis employed dual-color flow cytometry, facilitating high-throughput investigation of lipid peroxidation in foam cells.
  • Findings suggest lysosomal engulfment increases lipid peroxidation due to low-density lipoprotein accumulation.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af474ead7bf08b1ead3a64https://doi.org/10.1002/smo2.70015
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