Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies

View Full Paper

Ask AI

Bookmark

Most rhesus macaques developed a single lineage of V2 apex-neutralizing antibodies, showing cross-clade breadth.
The study detailed cryo-EM structures of 9 antibodies, revealing 8 different antibody classes and their recognition patterns.
A lineage exemplified by antibody V033-a.01 exhibited low somatic hypermutation while maintaining high breadth.
All identified neutralizing antibodies were linked to a specific reading frame of the DH3-15*01 gene, highlighting genetic consistency.

Discussion

No takes yet. Share an insight, caveat, or question.

This research uncovers genetic and structural insights into neutralizing antibodies in rhesus macaques, suggesting implications for vaccine design.

Roark et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

This research uncovers genetic and structural insights into neutralizing antibodies in rhesus macaques, suggesting implications for vaccine design.