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August 21, 2025Open Access

Figure S1 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

Benjamin C. Brim Andres F. Leon Erica L. Beatson Jessica D. Kindrick Kinjal Bhadresha Xiaohu Zhang Giulia C. Napoli Emily N. Risdon Keith T. Schmidt Kelli M. Wilson Crystal McKnight Erin Beck Carleen Klumpp‐Thomas Michele Ceribelli JuanJuan Yin Adam G. Sowalsky Douglas K. Price Cindy H. Chau Craig J. Thomas William D. Figg

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Key Points

Direct co-targeting of bcl-xl and mcl-1 increases efficacy in cancer models, enhancing treatment outcomes.
The analysis reveals elevated levels of AR, AR-V7, and pro-survival proteins in multiple prostate cancer cell lines.
Assessment employed protein level analysis across various prostate cancer cell lines to observe interactions.
The findings highlight the importance of targeting both bcl-xl and mcl-1 for improving therapies in prostate cancer.

Implication

Analysis of protein levels shows AR-V7 expression influences Bcl-xL and Mcl-1 synergy in prostate cancer.

Abstract

Figure S1 shows the protein levels of AR, AR-V7, Bcl-xL, Mcl-1, and Bcl-2 across several prostate cancer cell lines.

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Cite This Study

Brim et al. (2025) studied this question.

synapsesocial.com/papers/68af56f4ad7bf08b1eadce9d https://doi.org/10.1158/2767-9764.29957549

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
2Figure S4 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
3Figure S6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
4Figure S9 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025
5Figure S8 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models2025