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When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity

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Review highlights epigenetic mechanisms and DNA methylation's impact on obesity, suggesting novel therapeutic strategies.

Epigenomic modulation plays a critical role in the development and progression of obesity, affecting adipose tissue accumulation.
Recent evidence indicates abnormal DNA methylation and microRNA dysregulation contribute significantly to obesity pathogenesis.
This review analyzes tissue-specific epigenetic changes in key cells, including adipocytes and hepatocytes, enhancing insights into obesity.
Findings provide opportunities for developing new diagnostic biomarkers and targeted approaches to combat obesity.

Nikolaeva et al. (2025) studied this question.

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