Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Journal of the Endocrine SocietyOpen Access

Epigenetic changes associated with obesity-related metabolic comorbidities

View Full Paper
Ask AI
Bookmark
Share

Authors

ISIonel SandoviciUniversity of CambridgeTMTiago MoraisUniversidade do PortoMCMiguel ConstânciaUniversity of Cambridge

Discussion

Loading...

Member takes

Overview

Review explores epigenetic changes in metabolism and obesity-related insulin resistance, highlighting their implications.

Key Points

  • Epigenetic alterations are linked to obesity and metabolic comorbidities, indicating potential therapeutic targets.
  • Recent human studies show that epigenetic changes differentiate healthy obesity from those with insulin resistance and metabolic syndrome.
  • Mechanistic studies in mouse models reveal a significant role for epigenetic mechanisms in obesity-related metabolic dysfunction.
  • Peripheral blood biomarkers of epigenetic changes offer insights into obesity's metabolic impacts and future risk predictions.

Cite This Study

Sandovici et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3b54b1d3bfb60ee792https://doi.org/10.1210/jendso/bvaf129
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity2025 · 1 citations
  2. 2When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity2025 · 1 citations
  3. 3Epigenetics and Childhood Obesity: DNA Methylation Coordinates Environment and Gene Regulation2026
  4. 4OBESITY AS AN EPIGENETIC CONTINUUM: DEVELOPMENTAL ROOTS, ADIPOSE REMODELING, AND THE LIMITS OF REVERSIBILITY2026
  5. 5Nutrient-Sensitive Epigenetic Modifiers as Candidate Biomarkers of Metabolic Dysfunction in Obesity: A Nutrigenomic Review2026 · 2 citations