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June 17, 2026Physiological Genomics

Obesity as an Epigenetic Continuum: Developmental Roots, Adipose Remodeling, and the Limits of Reversibility

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Authors

LFLeon FerderSMSebastián García MenéndezWMWalter Manucha

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Overview

Randomized trial examines the impact of combined lifestyle interventions and medications on obesity-related outcomes, suggesting advanced strategies for treatment.

Key Points

  • This research explores how genetic and epigenetic factors influence obesity from developmental stages through adulthood. It aims to understand the implications of these interactions on treatment efficacy and reversibility.
  • Investigated the effects of prenatal factors on epigenetic marks and obesity outcomes in both childhood and adulthood.
  • Analyzed transcriptional and epigenomic profiles from human and mouse adipose tissue after weight loss.
  • Evaluated the impact of lifestyle interventions combined with dual- or selective-incretin-based drugs on body composition.
  • Identified significant weight loss and improved muscle function in participants receiving combined lifestyle interventions and medications.
  • Detected persistent epigenetic marks even after weight loss, indicating limits to the reversibility of obesity.
  • Showed varying evidence for the epigenetic impacts of anti-obesity drugs, highlighting the need for further studies on nutraceutical bioavailability.

Cite This Study

Ferder et al. (2026) studied this question.

synapsesocial.com/papers/6a323e06d50b63ecad207607https://doi.org/10.1152/physiolgenomics.00032.2026
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