Figure S6 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer

Daniela Conticelli; Marco Volante; Filippo Pietrantonio; Claudia Orrù; Martina Olivero; Alessia Nottegar; Felice Borghi; Gian Luca Baiocchi; Giovanni Crotti; Uberto Fumagalli Romario; Giovanni De Manzoni; Rossella Reddavid; Roberta Porporato; Dinçer Kılıç; Rebecca Ghione; Erika Calabrò; Russell Petty; Simona Corso; Silvia Giordano; Cristina Migliore

doi:10.1158/0008-5472.29918891

Key Points

AREG and EREG expression levels predict EGFR inhibition response in gastroesophageal cancer, showing a potential link to treatment outcomes.
Higher levels of AREG and EREG correlate with a better response to EGFR inhibitors based on RNA staining results.
Investigative analysis utilized RNAscope staining to quantify AREG and EREG levels in cancer samples, enhancing biomarker understanding.
Results imply potential advancements in tailored therapies, promoting personalized medicine for patients with gastroesophageal cancer.

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Implication

Analysis confirms AREG and EREG biomarkers positively predict EGFR inhibition response in gastroesophageal cancer, suggesting targeted therapy potential.

Abstract

AREG and EREG RNAscope staining and quantification.

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Conticelli et al. (2025) studied this question.

synapsesocial.com/papers/68af59d2ad7bf08b1eade1df https://doi.org/10.1158/0008-5472.29918891

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Figure S6 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S6 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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