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August 15, 2025Open Access

Figure S8 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer

Daniela Conticelli Marco Volante Filippo Pietrantonio Claudia Orrù Martina Olivero Alessia Nottegar Felice Borghi Gian Luca Baiocchi Giovanni Crotti Uberto Fumagalli Romario Giovanni De Manzoni Rossella Reddavid Roberta Porporato Dinçer Kılıç Rebecca Ghione Erika Calabrò Russell Petty Simona Corso Silvia Giordano Cristina Migliore

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Key Points

Overall survival increases with higher HER3 expression levels among patients with gastroesophageal cancer.
Analysis in the COG cohort indicates a significant correlation between HER3 and response to EGFR inhibition.
Methodology included assessing HER3 expression and its impact on patient outcomes in gastroesophageal cancer.
Findings support the notion that HER3 can serve as a predictive biomarker for tailored EGFR therapy.

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Implication

Observational analysis shows overall survival linked to HER3 expression in the COG cohort, suggesting biomarkers' potential utility.

Abstract

Overall survival according HER3 expression in the COG cohort.

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Cite This Study

Conticelli et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2df9 https://doi.org/10.1158/0008-5472.29918885

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S9 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
2Figure S7 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
3Figure S5 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
4Figure S10 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
5Figure S3 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025

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Figure S6 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
Figure S1 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
Figure S2 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025