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August 15, 2025

Figure S7 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer

Daniela Conticelli Marco Volante Filippo Pietrantonio Claudia Orrù Martina Olivero Alessia Nottegar Felice Borghi Gian Luca Baiocchi Giovanni Crotti Uberto Fumagalli Romario Giovanni De Manzoni Rossella Reddavid Roberta Porporato Dinçer Kılıç Rebecca Ghione Erika Calabrò Russell Petty Simona Corso Silvia Giordano Cristina Migliore

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Key Points

AREG and EREG biomarkers correlate with H-scores for response to EGFR inhibition in cancer, enhancing treatment predictions.
Correlation analysis reveals significant agreement in H-scores between pathologists for AREG and EREG biomarkers, enhancing diagnostic accuracy.
Assessment used H-score metrics across multiple gastroesophageal cancer samples to determine biomarker effectiveness.
These findings highlight the importance of AREG and EREG in selecting personalized therapies for cancer patients.

Implication

Evaluation shows AREG and EREG biomarkers predict response to EGFR inhibition in gastroesophageal cancer.

Abstract

H‐score correlation between the pathologists for AREG, EREG, and HER3 biomarkers.

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Cite This Study

Conticelli et al. (2025) studied this question.

synapsesocial.com/papers/68af5bafad7bf08b1eadf35d https://doi.org/10.1158/0008-5472.29918888

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S8 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
2Figure S5 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
3Figure S9 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
4Figure S10 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
5Figure S6 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025

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Figure S2 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
Figure S1 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025
Figure S3 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer2025