Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

Eui‐Jun Kim; Yidan Wang; Yulin Chen; M Ma; Peng Liu; Megan S. Bacabac; Jingjing Zhou; Christopher J. Fry; Jordan R. Hoffman; Menggang Yu; Lingjun Li; Aussie Suzuki; Shulin Li; Wei Xu

doi:10.1158/0008-5472.29918943

August 15, 2025Open Access

Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

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Key Points

MAP2K4 activity is heightened due to CARM1-mediated methylation, contributing to tumor growth.
CARM1 and MAP2K4 expression patterns inversely correlate in breast cancer subtypes, impacting treatment strategies.
Reverse expression patterns between CARM1 and MAP2K4 were investigated, showing their relationship in cancer progression.
This finding may enable targeted therapies against MAP2K4 in triple-negative breast cancer patients.

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Implication

Observational analysis reveals CARM1 enhances MAP2K4 activity in breast cancer, suggesting a targetable dependency.

Abstract

Reverse expression patterns of CARM1 and MAP2K4 in breast cancer subtypes and CARM1-mediated MAP2K4 methylation potentiates the downstream JNK activation

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Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68af59d2ad7bf08b1eade1f9 https://doi.org/10.1158/0008-5472.29918943

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Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

Key Points

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Implication

Abstract

Discussion

Cite This Study

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