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August 15, 2025Open Access

Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

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Authors

EKEui‐Jun KimUniversity of Wisconsin–MadisonYWYidan WangTechnical University of MunichYCYulin ChenWestlake University

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Overview

Observational analysis reveals CARM1 enhances MAP2K4 activity in breast cancer, suggesting a targetable dependency.

Key Points

  • MAP2K4 activity is heightened due to CARM1-mediated methylation, contributing to tumor growth.
  • CARM1 and MAP2K4 expression patterns inversely correlate in breast cancer subtypes, impacting treatment strategies.
  • Reverse expression patterns between CARM1 and MAP2K4 were investigated, showing their relationship in cancer progression.
  • This finding may enable targeted therapies against MAP2K4 in triple-negative breast cancer patients.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68af59d2ad7bf08b1eade1f9https://doi.org/10.1158/0008-5472.29918943
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 2 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  2. 2Supplementary Figure 5 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  3. 3Supplementary Figure 1 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  4. 4Supplementary Figure 7 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  5. 5Supplementary Figure 6 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025