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August 15, 2025Open Access

Supplementary Figure 5 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

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Authors

EKEui‐Jun KimYWYidan WangYCYulin Chen

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Overview

CARM1 and PI3K inhibition shows synergistic anti-growth effects in triple-negative breast cancer cell lines, suggesting a novel therapeutic approach.

Key Points

  • Synergistic anti-growth effects demonstrated a significant reduction in tumor cell proliferation.
  • In TNBC cell lines MDA-MB-231 and SUM159, combinations of CARM1 and PI3K inhibitors showed enhanced efficacy.
  • Observational analysis across multiple TNBC cell lines indicates promising therapeutic avenues.
  • These findings highlight potential for targeted therapies in combatting resistant breast cancer subtypes.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68af59d2ad7bf08b1eade1fchttps://doi.org/10.1158/0008-5472.29918937
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 7 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  2. 2Supplementary Figure 2 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  3. 3Supplementary Figure 6 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  4. 4Supplementary Figure 1 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  5. 5Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025