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August 15, 2025Open Access

Supplementary Figure 2 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

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Authors

EKEui‐Jun KimYWYidan WangYCYulin Chen

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Overview

CARM1 mediates MAP2K4 methylation, influencing oncogenic activity in triple-negative breast cancer cells, suggesting a new treatment target.

Key Points

  • MAP2K4 methylation enhances oncogenic functions in triple-negative breast cancer, indicating a potential therapeutic target.
  • Total MAP2K4 and methylated MAP2K4 levels were compared in MDA-MB-231 and Cal-51 cells and their CARM1 knockout counterparts.
  • Observational analysis across CARM1KO and parental cells reveals significant differences in MAP2K4 expression and localization.
  • These findings highlight an important targetable dependency for potential therapies in addressing triple-negative breast cancer.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2dedhttps://doi.org/10.1158/0008-5472.29918946
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 5 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  2. 2Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  3. 3Supplementary Figure 7 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  4. 4Supplementary Figure 1 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  5. 5Supplementary Figure 6 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025