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August 15, 2025Open Access

Supplementary Figure 7 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

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Authors

EKEui‐Jun KimYWYidan WangYCYulin Chen

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Overview

Combinational treatment with PI3Ki and CARM1i strongly inhibits tumor growth in models of triple-negative breast cancer, suggesting a potential therapeutic approach.

Key Points

  • Combinational treatment with PI3Ki and CARM1i effectively inhibits tumor growth, indicating a new strategy for treatment.
  • In vivo studies revealed significant tumor growth inhibition in PDXs and 4T1 tumors, emphasizing CARM1's role in oncogenesis.
  • The approach combines inhibition of both CARM1 and PI3K pathways, which targets MAP2K4 in triple-negative breast cancer.
  • These findings point to a targetable dependency in triple-negative breast cancer, highlighting potential implications for therapy.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68af59d2ad7bf08b1eade231https://doi.org/10.1158/0008-5472.29918931
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 6 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  2. 2Supplementary Figure 5 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  3. 3Supplementary Figure 2 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  4. 4Supplementary Figure 1 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  5. 5Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025