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August 15, 2025Open Access

Supplementary Figure 1 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer

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Authors

EKEui‐Jun KimUniversity of Wisconsin–MadisonYWYidan WangTechnical University of MunichYCYulin ChenWestlake University

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Implication

Treatment with EZM2302 increases carm1 and prmt1 levels in triple-negative breast cancer cells, suggesting new therapeutic options.

Key Points

  • CARM1-mediated MAP2K4 methylation enhances oncogenic functions in triple-negative breast cancer.
  • Treatment with EZM2302 raised CARM1 and PRMT1 levels significantly, indicating a possible target for therapy.
  • Observational analysis across various breast cancer cell lines revealed AKT activation status influenced by treatments.
  • Findings may enable the development of targeted therapies for patients with triple-negative breast cancer.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1d9https://doi.org/10.1158/0008-5472.29918949
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 5 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  2. 2Supplementary Figure 7 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  3. 3Supplementary Figure 2 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  4. 4Supplementary Figure 3 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025
  5. 5Supplementary Figure 6 from CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer2025