Synthesis of trifluoromethyl-functionalized benzo[de][1,8]naphthyridines via Rh(III)-catalyzed twofold C‑H activation of benzamidine hydrochlorides and annulation with CF3-imidoyl sulfoxonium ylides

Qihua Chen; Feng Han; Zhengkai Chen

doi:10.1039/d5nj03182f

January 1, 2025New Journal of Chemistry

Synthesis of trifluoromethyl-functionalized benzo[de][1,8]naphthyridines via Rh(III)-catalyzed twofold C‑H activation of benzamidine hydrochlorides and annulation with CF3-imidoyl sulfoxonium ylides

View Full Paper

Ask AI

Bookmark

Share

Key Points

This synthesis forms four new chemical bonds, enhancing molecular complexity.
The reaction is initiated through a Rh(III)-catalyzed twofold C‑H activation process.
Utilizing benzamidine hydrochlorides and CF3-imidoyl sulfoxonium ylides, innovative compounds are produced.
The findings suggest potential applications in organic synthesis and medicinal chemistry.

Implication

Rh(III)-catalyzed reactions form new chemical bonds in benzamidine derivatives, indicating novel synthesis methods.

Abstract

A Rh(III)-catalyzed twofold C‑H activation of benzamidine hydrochlorides and cascade annulation with CF3-imidoyl sulfoxonium ylides (TFISYs) has been disclosed. The transformation enables the formation of four new chemical bonds in...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af5d6fad7bf08b1eae0d9b https://doi.org/10.1039/d5nj03182f

View Full Paper

Ask AI

Bookmark

Share

Synthesis of trifluoromethyl-functionalized benzo[de][1,8]naphthyridines via Rh(III)-catalyzed twofold C‑H activation of benzamidine hydrochlorides and annulation with CF3-imidoyl sulfoxonium ylides

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of trifluoromethyl-functionalized benzo[de][1,8]naphthyridines via Rh(III)-catalyzed twofold C‑H activation of benzamidine hydrochlorides and annulation with CF3-imidoyl sulfoxonium ylides

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading