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August 26, 2025Journal of Clinical MedicineOpen Access

Age-Dependent Clinical Relevance of Lipoprotein(a): A Comprehensive Review from Childhood to Adulthood

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Authors

ANAthina NasoufidouAGAgni GlavaMMMaria Mavridou

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Overview

Comprehensive review uncovers the link between lipoprotein(a) levels and cardiovascular risk across ages, suggesting a need for tailored interventions.

Key Points

  • Elevated lipoprotein(a) levels are connected to earlier vascular dysfunction in children, and with increased cardiovascular diseases in adults.
  • In pediatric populations with high lipoprotein(a), early indicators of vascular issues may point to future risks, including familial hypercholesterolemia.
  • Emerging therapies targeting lipoprotein(a) could significantly reduce long-term cardiovascular risk when started early in life.
  • Prioritizing high-risk children and refining risk evaluation strategies may lead to improved cardiovascular outcomes into adulthood.

Cite This Study

Nasoufidou et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2c40https://doi.org/10.3390/jcm14176018
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Age – Dependent Clinical Relevance of Lipoprotein(a): A Comprehensive Review from Childhood to Adulthood2025
  2. 2Lp(a) in the Horizon of Diagnostics and Therapy2025 · 2 citations
  3. 3Lipoprotein(a), a moving target: from the primary to secondary prevention of atherothrombotic events2020 · 2 citations
  4. 4Lipoprotein(a) as an Independent Risk Factor and Prognostic Marker of Obstructive Coronary Artery Atherosclerosis in Young Patients: A Literature2025
  5. 5Atherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry2020 · 18 citations