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September 5, 2025Open Access

Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut

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Authors

JLJingkun LvXGXingting GuoRXRongwen Xi

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Overview

Research shows WNT and BMP gradients regulate regional enteroendocrine cell diversity in Drosophila, indicating their crucial developmental role.

Key Points

  • Regional patterning of enteroendocrine cells is established by WNT and BMP signaling gradients.
  • Three major enteroendocrine subtypes were analyzed in the Drosophila midgut across different stages.
  • The study highlights the importance of Notch-dependent and independent mechanisms in cell division modes.
  • Findings potentially indicate a conserved mechanism in mammals for maintaining enteroendocrine diversity.

Cite This Study

Lv et al. (2025) studied this question.

synapsesocial.com/papers/68bb3a352b87ece8dc954e4ehttps://doi.org/10.1101/2025.08.27.672561
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