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Synapse
October 23, 2025Open Access

Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut

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Authors

JLJingkun LvXGXingting GuoRXRongwen Xi

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Overview

Analysis reveals regional enteroendocrine cell diversity in Drosophila, indicating signaling pathways shape their distribution.

Key Points

  • Regional diversity of enteroendocrine cells is defined by signaling pathways along the Drosophila midgut.
  • Key findings include identification of progenitors contributing to EE diversity in maturation stages.
  • Assessment of Drosophila midgut revealed roles of Notch signaling in progenitor cell diversity.
  • Implications suggest conserved mechanisms of enteroendocrine diversity may extend to mammals.

Cite This Study

Lv et al. (2025) studied this question.

synapsesocial.com/papers/68f9f86eb2c35e10cc4e3e51https://doi.org/10.7554/elife.108542
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