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October 23, 2025Open Access

Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut

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Authors

JLJingkun LvXGXingting GuoRXRongwen Xi

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Overview

Investigation reveals spatiotemporal signaling regulates enteroendocrine cell diversity in Drosophila, suggesting implications for metazoan development.

Key Points

  • Regional diversity of enteroendocrine cells is regulated by spatiotemporal WNT and BMP signaling in Drosophila midgut.
  • Findings indicate that this patterning mechanism influences both development and adult phase.
  • Analysis of cell division modes for progenitors reveals both Notch-dependent and -independent contributions.
  • These insights suggest conserved mechanisms in metazoans for maintaining enteroendocrine diversity throughout life.

Cite This Study

Lv et al. (2025) studied this question.

synapsesocial.com/papers/68f9f86eb2c35e10cc4e3d17https://doi.org/10.7554/elife.108542.1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut2025
  2. 2Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the <i>Drosophila</i> midgut2025
  3. 3A regional regulatory axis shapes enteroendocrine cell morphology and function2026 · 1 citations
  4. 4Regenerative clustering of Enteroblasts in the<i>Drosophila</i>midgut revealed by a morphometric analysis2024
  5. 5Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development2025 · 1 citations