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August 28, 2025Open Access

Supplementary Figure S4 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection

Eunhee Yi Amit D. Gujar Dacheng Zhao Kentaro Suina Xue Jin Katharina Pardon Qinghao Yu Larisa Kagermazova Emmanuel E. Korsah Noah A. Dusseau Jef D. Boeke Anton G. Henssen Roel G.W. Verhaak

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Key Points

Cancer cells with extrachromosomal DNA (ecDNA) show different proliferation rates compared to those without it, suggesting ecDNA influences cell behavior.
Key evidence indicates significant disparities in proliferation, as cancer single-cell clones with ecDNA proliferate differently than those without.
This analysis assesses proliferation through comparative studies on cancer cells, focusing on the impact of ecDNA using lentiviral infection.
Understanding ecDNA's influence on cancer cell proliferation helps direct future therapeutic strategies targeting these cellular mechanisms.

Implication

This analysis compares cell proliferation in cancer single-cell clones with ecDNA, indicating the role of ecDNA.

Abstract

Figure S4. Comparison of cell proliferation between cancer single-cell clones with or without ecDNA.

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Cite This Study

Yi et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc9564f0 https://doi.org/10.1158/2767-9764.30001224

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
2Supplementary Figure S3 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
3Supplementary Figure S5 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
4Supplementary Figure S2 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
5Figure 5 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025

Data from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
Figure 6 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
Figure 3 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025