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August 28, 2025Open Access

Supplementary Figure S1 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection

Eunhee Yi Amit D. Gujar Dacheng Zhao Kentaro Suina Xue Jin Katharina Pardon Qinghao Yu Larisa Kagermazova Emmanuel E. Korsah Noah A. Dusseau Jef D. Boeke Anton G. Henssen Roel G.W. Verhaak

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Key Points

Gradual depletion of cancer cells occurs via treatment with extrachromosomal DNA.
Extrachromosomal DNA plays a crucial role in the cancer cell depletion process.
Lentiviral infection is the method used to introduce the extrachromosomal DNA.
The findings suggest that targeting extrachromosomal DNA may offer a novel cancer treatment approach.

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Implication

This approach reduces cancer cells through extrachromosomal DNA, highlighting its potential therapeutic benefits.

Abstract

Figure S1. Gradual depletion of cancer cells with ecDNA.

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Cite This Study

Yi et al. (2025) studied this question.

synapsesocial.com/papers/68bb421a2b87ece8dc958625 https://doi.org/10.1158/2767-9764.30001233

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
2Supplementary Figure S5 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
3Supplementary Figure S4 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
4Supplementary Figure S2 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
5Data from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025

Figure 6 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
Selective depletion of cancer cells with extrachromosomal DNA via lentiviral infection.2025
Figure 3 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025