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August 28, 2025Open Access

Supplementary Figure S3 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection

Eunhee Yi Amit D. Gujar Dacheng Zhao Kentaro Suina Xue Jin Katharina Pardon Qinghao Yu Larisa Kagermazova Emmanuel E. Korsah Noah A. Dusseau Jef D. Boeke Anton G. Henssen Roel G.W. Verhaak

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Key Points

Subpopulations with extrachromosomal DNA demonstrate reduced transduction efficiency.
Lentiviral infection was used to assess transduction in cancer cells, revealing delays in treatment response.
Reduction in transduction efficiency indicates a potential barrier to effective cancer therapy.
Findings underscore the importance of targeting ecDNA in cancer treatment strategies.

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Implication

Analysis shows lower transduction efficiency in subpopulations with extrachromosomal DNA, suggesting implications for cancer treatment.

Abstract

Figure S3. Subpopulations with ecDNA tend to show lower lentiviral transduction efficiency.

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Cite This Study

Yi et al. (2025) studied this question.

synapsesocial.com/papers/68bb3efd2b87ece8dc957b55 https://doi.org/10.1158/2767-9764.30001227

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S5 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
2Supplementary Figure S1 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
3Supplementary Figure S4 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
4Supplementary Figure S2 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
5Figure 6 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025

Figure 3 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
Data from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025
Figure 5 from Selective Depletion of Cancer Cells with Extrachromosomal DNA via Lentiviral Infection2025