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September 5, 2025Trends in Sciences

Potential of Probiotics as Adjuvant Therapy to Reduce Depressive Disorder Based on Dose and Duration: A Meta-Analysis

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Authors

HSHedya Nadhrati SururaSSSyahrial SyahrialEDElsi Fitri Dewi

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Overview

Meta-analysis shows probiotics may effectively reduce depressive symptoms in patients, indicating potential for clinical integration.

Key Points

  • Probiotics significantly reduce depressive symptoms in patients with major depressive disorder, improving mental health.
  • The study reported a standardized mean difference of -0.37, with a significant reduction noted in mild to moderate depressive disorders.
  • A meta-analysis of randomized controlled trials assessed the role of probiotics in clinical practice, following PRISMA guidelines.
  • Integration of probiotics into treatment plans supports evidence-based guidelines for managing depression and enhancing patient outcomes.

Cite This Study

Surura et al. (2025) studied this question.

synapsesocial.com/papers/68bb46bd6d6d5674bccfeaf1https://doi.org/10.48048/tis.2025.10622
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An updated systematic review and appraisal of the pathophysiologic mechanisms of probiotics in alleviating depression2025 · 3 citations
  2. 2Role of Probiotics in Management of Depressive Symptoms and Cognitive Impairment in Patients With Depression: An Updated Analysis of Trials2025
  3. 3Probiotics for major depressive disorder: a systematic review and meta-analysis2026
  4. 4Efficacy of prebiotics, probiotics, and postbiotics on depression: a systematic review and meta-analysis of randomized controlled trials2026
  5. 5Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial2024 · 11 citations