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July 16, 2025Nutritional Neuroscience

An updated systematic review and appraisal of the pathophysiologic mechanisms of probiotics in alleviating depression

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Authors

NSNur Najibah Yusra SulaimanNNNazifa Batrisyia Mohamad NizamNNNuruzzaman Noor

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Overview

Meta-analysis reveals probiotics improve depressive symptoms and cognitive function via gut microbiome modulation, indicating promising therapeutic potential.

Key Points

  • Probiotics significantly reduced depressive symptoms by a mean difference of -1.94 compared to placebo.
  • The Hamilton Depression Rating Scale showed a mean difference of -3.27, indicating substantial improvement.
  • Twelve randomized controlled trials were evaluated, revealing consistent benefits from specific probiotic strains.
  • Findings suggest a link between gut microbiota modulation and enhancement of cognitive function in depression management.

Cite This Study

Sulaiman et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccdcehttps://doi.org/10.1080/1028415x.2025.2531357
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Probiotics in Management of Depressive Symptoms and Cognitive Impairment in Patients With Depression: An Updated Analysis of Trials2025
  2. 2Potential of Probiotics as Adjuvant Therapy to Reduce Depressive Disorder Based on Dose and Duration: A Meta-Analysis2025
  3. 3Efficacy of prebiotics, probiotics, and postbiotics on depression: a systematic review and meta-analysis of randomized controlled trials2026
  4. 4Gut Microbiota Dysbiosis and Depression: Pathological Mechanisms and the Therapeutic Potential of Probiotic Interventions2025
  5. 5Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial2024 · 11 citations