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July 26, 2026Nutritional Neuroscience

Efficacy of prebiotics, probiotics, and postbiotics on depression: a systematic review and meta-analysis of randomized controlled trials

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Authors

NANazia AnjumZAZaheer AhmedFAFouzia Anjum

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Overview

Systematic review evaluates biotic interventions for managing depression, highlighting varying efficacy across types.

Key Points

  • Evaluate the effectiveness of prebiotics, probiotics, and postbiotics in treating depression through a systematic review.
  • Conducted a systematic review and meta-analysis of randomized controlled trials from 2016 to 2024.
  • Included 27 RCTs with control groups and standard depression rating scales.
  • Performed meta-analyses using standardized mean differences and subgroup analyses based on intervention duration.
  • Probiotics showed significant effects in long-duration subgroups (2 studies) with no heterogeneity, indicating potential benefits.
  • Prebiotics and postbiotics demonstrated no significant effects across durations, with variable levels of heterogeneity observed.
  • Overall certainty of evidence was rated as moderate due to inconsistencies among studies.

Cite This Study

Anjum et al. (2026) studied this question.

synapsesocial.com/papers/6a65a7e0d3aea3239cd78873https://doi.org/10.1080/1028415x.2026.2703621
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