Modest improvements in immune checkpoint blockade efficacy seen with high-fiber diet in breast cancer models, suggesting diet's role in treatment outcomes.
High–fiber-purified diet, but not chow, modestly enhances ICB efficacy in a breast cancer mouse model. A, Mean tumor volumes (calculated as the total volume of all individual mammary tumors per mouse) of MMTV-PyMT mice fed the indicated diets, with or without anti–PD-1 treatment. B, Fraction of mice free of a single primary tumor larger than 2,000 mm³. For A and B, n = 5 for isotype control and n = 10 for anti–PD-1 groups. C and D, Percentage of neutrophils and B cells among CD45⁺ cells in primary tumors collected at endpoint. n = 6 to 8 tumors collected from five mice for no treatment and 10 to 12 tumors from nine mice for anti–PD-1. *, P < 0.05. The log-rank test for B and an ANOVA with the Tukey post hoc test for other panels. Values are mean ± SEM.
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Roichman et al. (2025) studied this question.
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