Observational analysis reveals mixed effects of dietary fiber on immune checkpoint blockade efficacy in murine models, suggesting varied outcomes across tumor types.
Dietary cellulose tends to negatively affect ICB efficacy in Pold1D400A/D400A mice. A, Schematic showing Pold1D400A/D400A study design. B, Survival curves of Pold1D400A/D400A mice fed with the indicated HC or LC diets and treated with isotype control or anti–PD-1 antibody. Shown are plots for both sexes combined and males and females separately. n = 11 to 13, n = 6 to 8, and n = 5 to 6 mice per group for both sexes, males, and females, respectively. Overall survival curves are not significantly different. (A, Created with sciencefigures.org.)
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Roichman et al. (2025) studied this question.
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