Figure 4 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Purified cellulose enhances response to ICB therapy in YUMM1.1-9 but not in B16-OVA melanoma allografts. A and B, Mean tumor volumes and fraction of mice free of tumors larger than 500 mm³ for subcutaneous YUMM1.1-9 allografts in mice fed with chow or the indicated purified diets and treated with isotype control (for chow) or anti–PD-1. n = 9 to 11. C and D, Similar independent experiment for mice fed with chow, LC-, or HC-purified diets and treated with isotype control or anti–PD-1 antibody. n = 11. E and F, Mean tumor volumes and the fraction of mice free of tumors larger than 2,000 mm³ for subcutaneous B16-OVA allografts in mice fed chow or the indicated purified diets and treated with isotype control (for chow) or anti–PD-1. n = 7 to 12. *, P < 0.05; **, P < 0.01 for A, C, and E by a two-way ANOVA with the Tukey post hoc test at endpoint; values are mean ± SEM. For B, D, and F, log-rank test.