Supplementary Figure S3 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model

Ling Dong; Shiqi Zhang; Qimuge Wuri; Xueli Qu; Ke Zhang; Zongyu Cai; Yaru Qiao; Mengfan Feng; Xianghui Yu; Hui Wu; Jiaxin Wu; Wei Kong; Xianghui Yu; Haihong Zhang

doi:10.1158/1535-7163.30029252

September 2, 2025Open Access

Supplementary Figure S3 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model

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Key Points

Enhanced t-cell infiltration significantly improves antitumor effects in breast cancer.
Flow cytometry analysis revealed increased t-cell and mdsc activation in treated models.
The study utilized a murine model of breast cancer, facilitating insights into immunotherapy strategies.
Findings suggest that hmLIGHT may have therapeutic potential in enhancing vaccine responses.

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Implication

Observational analysis shows improved antitumor effects through enhanced t-cell infiltration and activation in the 4t1 breast cancer model, suggesting new vaccine strategies.

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Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5cb https://doi.org/10.1158/1535-7163.30029252

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Supplementary Figure S3 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S3 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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