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September 2, 2025Open Access

Supplementary Figure S4 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model

Ling Dong Shiqi Zhang Qimuge Wuri Xueli Qu Ke Zhang Zongyu Cai Yaru Qiao Mengfan Feng Xianghui Yu Hui Wu Jiaxin Wu Wei Kong Xianghui Yu Haihong Zhang

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Key Points

T-cell activation is significantly enhanced by hmLIGHT in the 4T1 breast cancer model.
Flow cytometry showed an increase in CD25+FoxP3+ Treg cells in the spleen after vaccination.
The intervention utilized hmLIGHT to promote T-cell infiltration into tumor sites.
These findings suggest hmLIGHT could improve vaccine efficacy through immunological mechanisms.

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Implication

Observational analysis revealed enhanced T-cell infiltration and activation in 4T1 breast cancer models, indicating significant vaccine effects.

Abstract

Representative flow cytometry profiles of CD25+FoxP3+ Treg cells in the spleen.

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Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5cf https://doi.org/10.1158/1535-7163.30029249

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
2Supplementary Figure S3 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
3Supplementary Figure S1 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
4Supplementary Figure S5 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
5Data from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
6Figure 3 from IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy2024
7Supplementary Figure S4 from XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies2024
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