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September 2, 2025Open Access

Supplementary Figure S1 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model

Ling Dong Shiqi Zhang Qimuge Wuri Xueli Qu Ke Zhang Zongyu Cai Yaru Qiao Mengfan Feng Xianghui Yu Hui Wu Jiaxin Wu Wei Kong Xianghui Yu Haihong Zhang

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Key Points

hmLIGHT increases the effectiveness of vaccines by facilitating T-cell infiltration into tumors.
In the 4T1 breast cancer model, T-cell activation is significantly enhanced with the use of hmLIGHT.
The study reveals a new approach for enhancing antitumor effects in breast cancer immunotherapy.
These findings indicate potential advancements in vaccine design targeting T-cell activation.

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Implication

Analysis shows hmLIGHT boosts antitumor effects through enhanced T-cell infiltration in 4T1 breast cancer, suggesting a novel vaccine strategy.

Abstract

Amino acid sequence alignment of hmLIGHT and hLIGHT.

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Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5d3 https://doi.org/10.1158/1535-7163.30029258

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Keep reading

Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
2Supplementary Figure S5 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
3Supplementary Figure S4 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
4Supplementary Figure S3 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
5Data from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
6Supplementary Figure 1 from HER1 (EGFR) and/or HER2 Inclusion Potentiates the Antitumor Effect Elicited by a HER3-Specific Monovalent Vaccine2025
7Supplementary Figure 3 from HER1 (EGFR) and/or HER2 Inclusion Potentiates the Antitumor Effect Elicited by a HER3-Specific Monovalent Vaccine2025
8Supplementary Figure 2 from HER1 (EGFR) and/or HER2 Inclusion Potentiates the Antitumor Effect Elicited by a HER3-Specific Monovalent Vaccine2025