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September 2, 2025Open Access

Supplementary Figure S2 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model

Ling Dong Shiqi Zhang Qimuge Wuri Xueli Qu Ke Zhang Zongyu Cai Yaru Qiao Mengfan Feng Xianghui Yu Hui Wu Jiaxin Wu Wei Kong Xianghui Yu Haihong Zhang

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Key Points

hmLIGHT significantly enhances vaccine antitumor effects in the 4T1 model, improving T-cell activation.
The key finding shows increased T-cell infiltration due to hmLIGHT, leading to better antitumor outcomes.
Observational analysis with flow cytometry was utilized to assess T-cell activities in this breast cancer model.
These findings highlight the potential of hmLIGHT in improving responses to cancer vaccines in clinical settings.

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Implication

Observational analysis reveals enhanced antitumor effects in 4T1 model with hmLIGHT, suggesting improved T-cell infiltration.

Abstract

Flow cytometry gating strategy for Figure 3F.

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Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5fd https://doi.org/10.1158/1535-7163.30029255

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1Supplementary Figure S4 from hmLIGHT Enhances Vaccine Antitumor Effects by Facilitating T-cell Infiltration and Activation in the 4T1 Breast Cancer Model2025
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